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Faculty of Biology, Chemistry & Earth Sciences

Biochemistry: Lab Prof. Dr. Andreas Möglich – Sensory Photoreceptors

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Stüven, Birthe; Stabel, Robert; Ohlendorf, Robert; Beck, Julian; Schubert, Roman; Möglich, Andreas
Characterization and engineering of photoactivated adenylyl cyclases
in Biological Chemistry vol. Online first (2019)
doi:10.1515/hsz-2018-0375 ...


Möglich, Andreas
An Open-Source, Cross-Platform Resource for Nonlinear Least-Squares Curve Fitting
in Journal of Chemical Education (2018)
doi:10.1021/acs.jchemed.8b00649 ...

Losi, Aba; Gardner, Kevin H.; Möglich, Andreas
Blue-Light Receptors for Optogenetics
in Chemical Reviews (2018)
doi:10.1021/acs.chemrev.8b00163 ...

Hennemann, Julia; Iwasaki, Roman S.; Grund, Tamara N.; Diensthuber, Ralph P.; Richter, Florian; Möglich, Andreas
Optogenetic Control by Pulsed Illumination
in ChemBioChem (2018)
doi:10.1002/cbic.201800030 ...

Möglich, Andreas
Signaltransduktion einer lichtregulierten Sensorhistidinkinase
in Nachrichten aus der Chemie vol. 66 (2018) issue 2. - pp. 123-126
doi:10.1002/nadc.20184058953 ...


Engelhard, Christopher; Diensthuber, Ralph P.; Möglich, Andreas; Bittl, Robert
Blue-light reception through quaternary transitions
in Scientific Reports vol. 7 (2017) issue 1
doi:10.1038/s41598-017-01497-7 ...

Mayer, Günter; Möglich, Andreas
Editorial overview: Chemical biotechnology : Interdisciplinary approaches for the engineering of nucleic acids, proteins and cells
in Current Opinion in Biotechnology (2017)
doi:10.1016/j.copbio.2017.08.001 ...

Stabel, Robert; Möglich, Andreas
Die Kontrolle zyklischer Nukleotide mittels Licht
in BIOspektrum vol. 23 (2017) issue 4. - pp. 384-387
doi:10.1007/s12268-017-0813-5 ...

Nack, Jennifer; Möglich, Andreas
Optische Kontrolle zellulärer Prozesse
in Nachrichten aus der Chemie vol. 65 (2017) issue 3. - pp. 309-313
doi:10.1002/nadc.20174060764 ...

Hauf, Mathias; Richter, Florian; Schneider, Tobias; Faidt, Thomas; Martins, Berta M.; Baumann, Tobias; Durkin, Patrick; Dobbek, Holger; Jacobs, Karin; Möglich, Andreas; Budisa, Nediljko
Photoactivatable mussel-based underwater adhesive proteins by an expanded genetic code
in ChemBioChem (2017)
doi:10.1002/cbic.201700327 ...

Stabel, Robert; Stüven, Birthe; Ohlendorf, Robert; Möglich, Andreas
Primer-Aided Truncation for the Creation of Hybrid Proteins
in Methods in Molecular Biology vol. 1596 (2017) . - pp. 287-304
doi:10.1007/978-1-4939-6940-1_18 ...

Berntsson, Oskar; Diensthuber, Ralph P.; Panman, Matthijs R.; Björling, Alexander; Gustavsson, Emil; Hoernke, Maria; Hughes, Ashley J.; Henry, Léocadie; Niebling, Stephan; Takala, Heikki; Ihalainen, Janne A.; Newby, Gemma; Kerruth, Silke; Heberle, Joachim; Liebi, Marianne; Menzel, Andreas; Henning, Robert; Kosheleva, Irina; Möglich, Andreas; Westenhoff, Sebastian
Sequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase
in Nature Communications vol. 8 (2017)
doi:10.1038/s41467-017-00300-5 ...

Richter, Florian; Fonfara, Ines; Gelfert, Renate; Nack, Jennifer; Charpentier, Emmanuelle; Möglich, Andreas
Switchable Cas9
in Current Opinion in Biotechnology vol. 48 (2017) . - pp. 119-126
doi:10.1016/j.copbio.2017.03.025 ...

Berntsson, Oskar; Diensthuber, Ralph P.; Panman, Matthijs R.; Björling, Alexander; Hughes, Ashley J.; Henry, Léocadie; Niebling, Stephan; Newby, Gemma; Liebi, Marianne; Menzel, Andreas; Henning, Robert; Kosheleva, Irina; Möglich, Andreas; Westenhoff, Sebastian
Time-Resolved X-Ray Solution Scattering Reveals the Structural Photoactivation of a Light-Oxygen-Voltage Photoreceptor
in Structure vol. 25 (2017) . - pp. 1-6
doi:10.1016/j.str.2017.04.006 ...


Ohlendorf, Robert; Schumacher, Charlotte Helene; Richter, Florian; Möglich, Andreas
Library-Aided Probing of Linker Determinants in Hybrid Photoreceptors
in ACS Synthetic Biology (2016)
doi:10.1021/acssynbio.6b00028 ...

Richter, Florian; Fonfara, Ines; Bouazza, Boris; Schumacher, Charlotte Helene; Bratovič, Majda; Charpentier, Emmanuelle; Möglich, Andreas
Engineering of temperature- and light-switchable Cas9 variants
in Nucleic Acids Research vol. 44 (2016) issue 20. - pp. 10003-10014
doi:10.1093/nar/gkw930 ...

Schumacher, Charlotte Helene; Körschen, Heinz G.; Nicol, Christopher; Gasser, Carlos; Seifert, Reinhard; Schwärzel, Martin; Möglich, Andreas
A Fluorometric Activity Assay for Light-Regulated Cyclic-Nucleotide-Monophosphate Actuators
in Methods in Molecular Biology vol. 1408 (2016) . - pp. 93-105
doi:10.1007/978-1-4939-3512-3_7 ...

Ziegler, Thea; Schumacher, Charlotte Helene; Möglich, Andreas
Guidelines for Photoreceptor Engineering
in Methods in Molecular Biology vol. 1408 (2016) . - pp. 389-403
doi:10.1007/978-1-4939-3512-3_27 ...


Yee, Estelle F.; Diensthuber, Ralph P.; Vaidya, Anand T.; Borbat, Peter P.; Engelhard, Christopher; Freed, Jack H,.; Bittl, Robert; Möglich, Andreas; Crane, Brian R.
Signal transduction in light-oxygen-voltage receptors lacking the adduct-forming cysteine residue
in Nature Communications vol. 6 (2015) . - pp. 10079
doi:10.1038/ncomms10079 ...

Ziegler, Thea; Möglich, Andreas
Photoreceptor engineering
in Frontiers in Molecular Biosciences vol. 2 (2015) . - pp. 30
doi:10.3389/fmolb.2015.00030 ...

Richter, Florian; Scheib, Ulrike; Mehlhorn, Jennifer; Schubert, Roman; Wietek, Jonas; Gernetzki, Oliver; Hegemann, Peter; Mathes, Tilo; Möglich, Andreas
Upgrading a microplate reader for photobiology and all-optical experiments
in Photochemical & Photobiological Sciences vol. 14 (2015) issue 2. - pp. 270-279
doi:10.1039/c4pp00361f ...


Diensthuber, Ralph P.; Engelhard, Christopher; Lemke, Nora; Gleichmann, Tobias; Ohlendorf, Robert; Bittl, Robert; Möglich, Andreas
Biophysical, mutational, and functional investigation of the chromophore-binding pocket of light-oxygen-voltage photoreceptors
in ACS Synthetic Biology vol. 3 (2014) issue 11. - pp. 811-819
doi:10.1021/sb400205x ...

Gasser, Carlos; Taiber, Sandra; Yeh, Chen-Min; Wittig, Charlotte Helene; Hegemann, Peter; Ryu, Soojin; Wunder, Frank; Möglich, Andreas
Engineering of a red-light-activated human cAMP/cGMP-specific phosphodiesterase
in Proceedings of the National Academy of Sciences of the United States of America vol. 111 (2014) issue 24. - pp. 8803-8808
doi:10.1073/pnas.1321600111 ...


Gleichmann, Tobias; Diensthuber, Ralph P.; Möglich, Andreas
Charting the signal trajectory in a light-oxygen-voltage photoreceptor by random mutagenesis and covariance analysis
in The Journal of Biological Chemistry vol. 288 (2013) issue 41. - pp. 29345-29355
doi:10.1074/jbc.M113.506139 ...

Engelhard, Christopher; Raffelberg, Sarah; Tang, Yifen; Diensthuber, Ralph P.; Möglich, Andreas; Losi, Aba; Gärtner, Wolfgang; Bittl, Robert
A structural model for the full-length blue light-sensing protein YtvA from Bacillus subtilis, based on EPR spectroscopy
in Photochemical & Photobiological Sciences vol. 12 (2013) issue 10. - pp. 1855-1863
doi:10.1039/c3pp50128k ...

Möglich, Andreas; Hegemann, Peter
Biotechnology : Programming genomes with light
in Nature vol. 500 (2013) issue 7463. - pp. 406-408
doi:10.1038/500406a ...

Diensthuber, Ralph P.; Bommer, Martin; Gleichmann, Tobias; Möglich, Andreas
Full-length structure of a sensor histidine kinase pinpoints coaxial coiled coils as signal transducers and modulators
in Structure vol. 21 (2013) issue 7. - pp. 1127-1136
doi:10.1016/j.str.2013.04.024 ...

Diensthuber, Ralph P.; Ohlendorf, Robert; Gleichmann, Tobias; Möglich, Andreas
Lichtregulierte Genexpression
in BIOspektrum vol. 19 (2013) issue 2. - pp. 149-151
doi:10.1007/s12268-013-0286-0 ...

Rockwell, Nathan C.; Ohlendorf, Robert; Möglich, Andreas
Cyanobacteriochromes in full color and three dimensions
in Proceedings of the National Academy of Sciences of the United States of America vol. 110 (2013) issue 3. - pp. 806-807
doi:10.1073/pnas.1220690110 ...

Moffat, Keith; Zhang, Feng; Hahn, Klaus; Möglich, Andreas
The Biophysics and Engineering of Signaling Photoreceptors
Hegemann, Peter ; Sigrist, Stephan (Hrsg.): Optogenetics - Berlin: De Gruyter, 2013. - pp. 7-20


Ohlendorf, Robert; Vidavski, Roee R.; Eldar, Avigdor; Moffat, Keith; Möglich, Andreas
From dusk till dawn : one-plasmid systems for light-regulated gene expression
in Journal of Molecular Biology vol. 416 (2012) issue 4. - pp. 534-542
doi:10.1016/j.jmb.2012.01.001 ...


Hegemann, Peter; Möglich, Andreas
Channelrhodopsin engineering and exploration of new optogenetic tools
in Nature Methods vol. 8 (2011) issue 1. - pp. 39-42
doi:10.1038/nmeth.f.327 ...


Möglich, Andreas; Moffat, Keith
Engineered photoreceptors as novel optogenetic tools
in Photochemical & Photobiological Sciences vol. 9 (2010) issue 10. - pp. 1286-1300
doi:10.1039/c0pp00167h ...

Möglich, Andreas; Ayers, Rebecca A.; Moffat, Keith
Addition at the molecular level : signal integration in designed Per-ARNT-Sim receptor proteins
in Journal of Molecular Biology vol. 400 (2010) issue 3. - pp. 477-486
doi:10.1016/j.jmb.2010.05.019 ...

Möglich, Andreas; Yang, Xiaojing; Ayers, Rebecca A.; Moffat, Keith
Structure and function of plant photoreceptors
in Annual Review of Plant Biology vol. 61 (2010) . - pp. 21-47
doi:10.1146/annurev-arplant-042809-112259 ...


Möglich, Andreas; Ayers, Rebecca A.; Moffat, Keith
Structure and signaling mechanism of Per-ARNT-Sim domains
in Structure vol. 17 (2009) issue 10. - pp. 1282-1294
doi:10.1016/j.str.2009.08.011 ...

Möglich, Andreas; Ayers, Rebecca A.; Moffat, Keith
Design and signaling mechanism of light-regulated histidine kinases
in Journal of Molecular Biology vol. 385 (2009) issue 5. - pp. 1433-1444
doi:10.1016/j.jmb.2008.12.017 ...


Möglich, Andreas; Moffat, Keith
Structural basis for light-dependent signaling in the dimeric LOV domain of the photosensor YtvA
in Journal of Molecular Biology vol. 373 (2007) issue 1. - pp. 112-126
doi:10.1016/j.jmb.2007.07.039 ...


Möglich, Andreas; Joder, Karin; Kiefhaber, Thomas
End-to-end distance distributions and intrachain diffusion constants in unfolded polypeptide chains indicate intramolecular hydrogen bond formation
in Proceedings of the National Academy of Sciences of the United States of America vol. 103 (2006) issue 33. - pp. 12394-12399
doi:10.1073/pnas.0604748103 ...


Möglich, Andreas; Weinfurtner, Daniel; Gronwald, Wolfram; Maurer, Till; Kalbitzer, Hans Robert
PERMOL : restraint-based protein homology modeling using DYANA or CNS
in Bioinformatics vol. 21 (2005) issue 9. - pp. 2110-2111
doi:10.1093/bioinformatics/bti276 ...

Krieger, Florian; Möglich, Andreas; Kiefhaber, Thomas
Effect of proline and glycine residues on dynamics and barriers of loop formation in polypeptide chains
in Journal of the American Chemical Society vol. 127 (2005) issue 10. - pp. 3346-3352
doi:10.1021/ja042798i ...

Möglich, Andreas; Krieger, Florian; Kiefhaber, Thomas
Molecular basis for the effect of urea and guanidinium chloride on the dynamics of unfolded polypeptide chains
in Journal of Molecular Biology vol. 345 (2005) issue 1. - pp. 153-162
doi:10.1016/j.jmb.2004.10.036 ...

Möglich, Andreas; Weinfurtner, Daniel; Maurer, Till; Gronwald, Wolfram; Kalbitzer, Hans Robert
A restraint molecular dynamics and simulated annealing approach for protein homology modeling utilizing mean angles
in BMC Bioinformatics vol. 6 (2005) . - pp. 91
doi:10.1186/1471-2105-6-91 ...


Möglich, Andreas; Koch, Brigitte; Gronwald, Wolfram; Hengstenberg, Wolfgang; Brunner, Eike; Kalbitzer, Hans Robert
Solution structure of the active-centre mutant I14A of the histidine-containing phosphocarrier protein from Staphylococcus carnosus
in European Journal of Biochemistry vol. 271 (2004) issue 23-24. - pp. 4815-4824
doi:10.1111/j.1432-1033.2004.04447.x ...

Martin, Georges; Möglich, Andreas; Keller, Walter; Doublié, Sylvie
Biochemical and structural insights into substrate binding and catalytic mechanism of mammalian poly(A) polymerase
in Journal of Molecular Biology vol. 341 (2004) issue 4. - pp. 911-925
doi:10.1016/j.jmb.2004.06.047 ...

Güthe, Sarah; Kapinos, Larisa; Möglich, Andreas; Meier, Sebastian; Grzesiek, Stephan; Kiefhaber, Thomas
Very fast folding and association of a trimerization domain from bacteriophage T4 fibritin
in Journal of Molecular Biology vol. 337 (2004) issue 4. - pp. 905-915
doi:10.1016/j.jmb.2004.02.020 ...


Gröger, Christian; Möglich, Andreas; Pons, Miguel; Koch, Brigitte; Hengstenberg, Wolfgang; Kalbitzer, Hans Robert; Brunner, Eike
NMR-spectroscopic mapping of an engineered cavity in the I14A mutant of HPr from Staphylococcus carnosus using xenon
in Journal of the American Chemical Society vol. 125 (2003) issue 29. - pp. 8726-8727
doi:10.1021/ja030113t ...


Möglich, Andreas; Wenzler, Michael; Kramer, Frank; Glaser, Steffen J.; Brunner, Eike
Determination of residual dipolar couplings in homonuclear MOCCA-SIAM experiments
in Journal of Biomolecular NMR vol. 23 (2002) issue 3. - pp. 211-219
doi:10.1023/A:1019841602348 ...

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